The Histone Deacetylase HstD Regulates Fungal Growth, Development and Secondary Metabolite Biosynthesis in Aspergillus terreus

Histone acetylation modification significantly affects secondary metabolism in filamentous fungi. However, how histone regulates metabolite synthesis the lovastatin (a lipid-lowering drug) producing Aspergillus terreus remains unknown because protein is involved and has been identified this species. Here, fungal-specific deacetylase gene, hstD, was characterized through functional genomics two marine-derived A. strains, Mj106 RA2905. The results showed that ablation of HstD resulted reduced mycelium growth, less conidiation, decreased biosynthesis but increased terrein biosynthesis. unlike its homologs yeast, not required for fungal responses to DNA damage agents, indicating likely plays a novel role repair process terreus. Furthermore, loss significant upregulation H3K56 H3K27 when compared wild type, suggesting epigenetic functions HstD, as deacetylase, target H3K56. Additionally, set no-histone targets with potential roles were first time using acetylated proteomic analysis. In conclusion, we provide comprehensive analysis or non-histone growth development, response,